Sister Mary Joseph nodule.

To cite: Menzies S, Chotirmall SH, Wilson G, et al. BMJ Case Rep Published online: [please include Day Month Year] doi:10.1136/bcr-2014206808 DESCRIPTION A 72-year-old woman was referred to our emergency department with general malaise and an elevated international normalised ratio (INR) at 15. Of note, she was on Warfarin therapy for atrial fibrillation. She appeared cachectic and frail. On examination, her abdomen showed no visible umbilical lesion, however a subcutaneous nodule was palpable in the superior aspect of the umbilicus. This raised the suspicion of malignant metastases in view of her weight loss and abnormal INR. CT of the thorax, abdomen and pelvis illustrated a pancreatic mass with liver metastases, ascites and a Sister Mary Joseph nodule (figures 1 and 2). Histology confirmed metastatic pancreatic adenocarcinoma. She was palliatively managed and passed away less than 4 weeks following the admission. The ‘Sister Mary Joseph’ sign is an umbilical nodule consequent to metastatic spread from an intra-abdominal or gynaecological malignancy. Baluff first described umbilical metastases in 1854. However, Sister Mary Joseph, surgical assistant to William J Mayo, noted the association between an intra-abdominal malignancy and an umbilical nodule back in 1928. Interestingly, William J Mayo was the son of the founder of the well-known Mayo Clinic, where Sister Joseph spent many decades working in the field of nursing. 3 Mechanisms of spread to the umbilicus remain poorly understood but have been postulated as direct haematogenous or transperitoneal spread through lymphatics or alternatively through remnant embryological structures. While associated with poor prognosis as a presenting sign, it implies advanced metastatic disease as illustrated by our case. Learning points